Massachusetts General Hospital | 55 Fruit Street | White 5Click Here to Email Us
617 726 9252

Success

Success to Date

To date, the ARC has participated in more than 250 clinical research studies. Activities have spanned regulatory reporting, patient recruitment, data collection, grant applications, and statistical analysis. Below is a list of selected publications and grants that have been funded as a result of support from the ARC.

Recent Success Stories

The ARC team recently attended the IARS Annual Meeting in Denver, CO, where they presented posters on exciting new research conducted by our team. Pictured left to right are Clinical Research Coordinators, Julia Bertsch, Alexis Novak, Marissa Albanese, Sarah Baker, and Data Analyst, Matthew Smith.

Members of the ARC previously participated in recruitment, data collection and device support for Dr. Bao’s Hypotension Prediction Index (HPI) study. This included enrollment of more than 30 patients in under two months. Pictured left to right are Ning Jiang (Senior Research Coordinator), Dr. Xiaodong Bao (Site Principal Investigator) and Katie Luchette (Clinical Research Coordinator).

Selected Publications

A selection of publications supported by the ARC team is listed below, with names of specific ARC authors in bold.

  • Wu F, Wang J, Deng H, Li R, Mueller A, Houle TT. Effect of Intraoperative Methadone on Postoperative Pain and Opioid Consumption in Oral and Maxillofacial Surgeries. International Anesthesia Research Society 2023 Annual Meeting; 2023 Apr 14-16; Denver, CO.
  • Kinsman BJ, Smolinski-Zhao S, Soljacic FD, Mueller AL, Vazquez R, Houle TT, Ruscic KJ. Lighter Depth of Sedation Is Associated with Shorter Lymphangiogram Procedure Duration. International Anesthesia Research Society 2023 Annual Meeting; 2023 Apr 14-16; Denver, CO.
  • Muldoon A, Carr B, Khajavi B, Martin A, Robinson M, Bertsch J, Novak A, Parab L, Mueller A, Albanese M, Qu J, Franceschini MA, Carp SA. Non-invasive monitoring of cerebral hemodynamics using near-infrared spectroscopy and diffuse correlation spectroscopy during transcatheter aortic valve replacement surgery. SPIE Clinical and Translational Neurophotonics 2023 Conference; 2023 Jan 28; San Francisco, CA.
  • Qu JZ, Mueller A, McKay TB, Westover MB, Shelton KT, Shaefi S, D’Alessandro DA, Berra L, Brown EN, Houle TT, Akeju O; MINDDS Study Team. Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): A single-centre, parallel-arm, randomised, placebo-controlled superiority trial. EClinicalMedicine. 2022 Dec 24;56:101796. doi: 10.1016/j.eclinm.2022.101796. PMID: 36590787; PMCID: PMC9800196.
  • Xuan C, Yan W, Wang D, Li C, Ma H, Mueller A, Chin V, Houle TT, Wang J. Efficacy of preemptive analgesia treatments for the management of postoperative pain: a network meta-analysis. Br J Anaesth. 2022 Dec;129(6):946-958. doi: 10.1016/j.bja.2022.08.038. Epub 2022 Oct 26. PMID: 36404458.
  • Gibson LE, Knudsen AS, Arney D, Deng H, Sims NM, Peterfreund RA. Lag times to steady state drug delivery by continuous intravenous infusion: direct comparison of peristaltic and syringe pump performance identifies contributions from infusion system dead volume and pump startup characteristics. J Clin Monit Comput. 2022 Oct;36(5):1489-1498. doi: 10.1007/s10877-021-00790-1. Epub 2021 Dec 8. Erratum in: J Clin Monit Comput. 2022 Jan 6;: PMID: 34878612.
  • Ma X, Mei X, Tang T, Wang M, Wei X, Zheng H, Cao J, Zheng H, Cody K, Xiong L, Marcantonio ER, Xie Z, Shen Y. Preoperative homocysteine modifies the association between postoperative C-reactive protein and postoperative delirium. Front Aging Neurosci. 2022 Sep 21;14:963421. doi: 10.3389/fnagi.2022.963421. PMID: 36212043; PMCID: PMC9532549.
  • Nanji KC, Garabedian PM, Langlieb ME, Rui A, Tabayoyong LL, Sampson M, Deng H, Boxwala A, Minehart RD, Bates DW. Usability of a perioperative medication-related clinical decision support software application: a randomized controlled trial. J Am Med Inform Assoc. 2022 Jul 12;29(8):1416-1424. doi: 10.1093/jamia/ocac035. PMID: 35575780; PMCID: PMC9277651.
  • Liang F, Baldyga K, Quan Q, Khatri A, Choi S, Wiener-Kronish J, Akeju O, Westover BM, Cody K, Shen Y, Marcantonio ER, Xie Z. Preoperative Plasma Tau-PT217 and Tau-PT181 Are Associated With Postoperative Delirium. Ann Surg. 2022 Jul 6. doi: 10.1097/SLA.0000000000005487. Epub ahead of print. PMID: 35794069.
  • McKay TB, Rhee J, Colon K, Adelsberger K, Turco I, Mueller A, Qu J, Akeju O. Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022 Jan;36(1):118-124. doi: 10.1053/j.jvca.2021.05.002. Epub 2021 May 12. PMID: 34112563; PMCID: PMC8586054.
  • Rosenbloom JM, Deng H, Mueller AL, Alegria M, Houle TT; Collaborators from the Multicenter Perioperative Outcomes Group. Race/Ethnicity and Duration of Anesthesia for Pediatric Patients in the US: a Retrospective Cohort Study. J Racial Ethn Health Disparities. 2022 May 3. doi: 10.1007/s40615-022-01318-2. Epub ahead of print. PMID: 35505152.
  • Eke OF, Selame L, Gullikson J, Deng H, Dutta S, Shokoohi H. Timing of pericardiocentesis and clinical outcomes: Is earlier pericardiocentesis better? Am J Emerg Med. 2022 Apr;54:202-207. doi: 10.1016/j.ajem.2022.01.062. Epub 2022 Feb 3. PMID: 35176659.
  • Emery, A., Deng, H., Yang, Q., Mueller, A., Houle, T., & Wang, J. (2022). The effects of paravertebral nerve blockade on post-operative pain for patients undergoing simultaneous autologous rib grafting and orthognathic surgery: a retrospective pilot study. Journal Of Oral And Maxillofacial Anesthesia, 1(1). doi:10.21037/joma-22-23
  • McKay TB, Qu J, Liang F, Mueller A, Wiener-Kronish J, Xie Z, Akeju O. Tau as a serum biomarker of delirium after major cardiac surgery: a single centre case-control study. Br J Anaesth. 2022 Jul;129(1):e13-e16. doi: 10.1016/j.bja.2022.04.002. Epub 2022 Apr 22. PMID: 35465951; PMCID: PMC9428914.
  • Austin DR, Lai Y, Mueller A, Shelton KT. Inhaled Pulmonary Vasodilator Utilization and Cost Following Initiation of a Protocol in a Quaternary Academic Heart Center Intensive Care Unit. J Cardiothorac Vasc Anesth. 2022 May;36(5):1343-1349. doi: 10.1053/j.jvca.2021.11.005. Epub 2021 Nov 26. PMID: 35065876.
  • Gianni S, Fenza RD, Morais CCA, Fakhr BS, Mueller AL, Yu B, Carroll RW, Ichinose F, Zapol WM, Berra L. High-Dose Nitric Oxide From Pressurized Cylinders and Nitric Oxide Produced by an Electric Generator From Air. Respir Care. 2022 Feb;67(2):201-208. doi: 10.4187/respcare.09308. Epub 2021 Aug 19. PMID: 34413210.
  • Xuan C, Yan W, Wang D, Li C, Ma H, Mueller A, Deng H, Houle T, Wang J. Efficacy of different analgesia treatments for abdominal surgery: A network meta-analysis. Eur J Pain. 2022 Mar;26(3):567-577. doi: 10.1002/ejp.1880. Epub 2021 Nov 5. PMID: 34698423.
  • Lu SY, Ortoleva J, Colon K, Mueller A, Laflam A, Shelton K, Dalia AA. Association Between Body Mass Index and Outcomes in Venoarterial Extracorporeal Membrane Oxygenation. Anesth Analg. 2022 Feb 1;134(2):341-347. doi: 10.1213/ANE.0000000000005689. PMID: 34881861.
  • Gorky J, Karinja S, Liu L, Smith M, Mueller AL, Houle TT, Eberlin K, Ruscic KJ. Towards optimal anesthetic management of peripheral neuroma excision surgery. International Anesthesia Research Society 2023 Annual Meeting; 2023 Apr 14-16; Denver, CO.
  • Joshi A, Mueller A, Naseem H, Munoz-Acuna R, O’Connor S, Monteith E, Valencia J, Shankar P, O’Gara BP, Shaefi S. Intraoperative Oxygen Concentration and Pulmonary Complications after Cardiac Surgery – A Secondary Analysis of a Randomized Controlled Trial. Society of Cardiovascular Anesthesiologists Annual Meeting; 2022 May 14-17; Palm Springs, CA.
  • Joshi A, Mueller A, Naseem H, Munoz-Acuna R, O’Connor S, Monteith E, Valencia J, Shankar P, O’Gara BP, Shaefi S. Intraoperative Oxygen Concentration and Pulmonary Complications after Cardiac Surgery – A Secondary Analysis of a Randomized Controlled Trial. IARS 2022 Annual Meeting and International Science Symposium; 2022 March 18-21; Honolulu, HI.
  • Reed A, Rackliffe J, Bezreh N, Zoeller K, Ronin J, Chipman D, Donahue V, Mueller A, Woo S, Crowley C, Jassar A, Shelton K. A Study to Evaluate the Implementation of a Nurse Driven Extubation Protocol in a Cardiothoracic Intensive Care Unit. American Association for Thoracic Surgery 102nd Annual Meeting; 2022 May 14-17; Boston, MA.
  • Rosenbloom JM, Deng H, Mueller AL, Alegria M, Houle TT; Collaborators from the Multicenter Perioperative Outcomes Group. Race/Ethnicity and Duration of Anesthesia for Pediatric Patients in the US: a Retrospective Cohort Study. J Racial Ethn Health Disparities. 2022 May 3. doi: 10.1007/s40615-022-01318-2. PMID: 35505152.
  • McKay TB, Qu J, Liang F, Mueller A, Wiener-Kronish J, Xie Z, Ajeju O. Tau as a serum biomarker of delirium after major cardiac surgery: a single centre case-control study. BJA, 2022 Apr. https://doi.org/10.1016/j.bja.2022.04.002.
  • Eke OF, Selame L, Gullikson J, Deng H, Dutta S, Shokoohi H. Timing of pericardiocentesis and clinical outcomes: Is earlier pericardiocentesis better? Am J Emerg Med. 2022 Apr. https://doi.org/10.1016/j.ajem.2022.01.062.
  • Aiudi CM, Oliver JJ, Chowatia PA, Priya A, Mueller AL, Dalia AA. Perioperative Emergencies: Who, What, When, Where, Why? J Cardiothorac Vasc Anesth. 2021 Nov;35(11):3248-3254. doi: 10.1053/j.jvca.2021.02.015. Epub 2021 Feb 9. PMID: 33663977.
  • Austin DR, Lai Y., Mueller A, Shelton KT. Inhaled Pulmonary Vasodilator Utilization and Cost Following Initiation of a Protocol in a Quaternary Academic Heart Center Intensive Care Unit. J Cardiothorac Vasc Anesth. 2021 Nov; https://doi.org/10.1053/j.jvca.2021.11.005.
  • Xuan C, Yan W, Wang D, Li C, Ma H, Mueller A, Deng H, Houle T, Wang J. Efficacy of different analgesia treatments for abdominal surgery: a network meta-analysis. Eur J Pain. 2021 Oct 26. doi: 10.1002/ejp.1880. Epub ahead of print. PMID: 34698423.
  • Safavi KC, Deng H, Driscoll W, Nikolov M, Tolia K, Wiener-Kronish JP. A Remote Surveillance Platform to Monitor General Care Ward Surgical Patients for Acute Physiologic Deterioration. Anesth Analg. 2021 Oct 1;133(4):933-939. doi: 10.1213/ANE.0000000000005530. PMID: 33830955; PMCID: PMC8415733.
  • Gianni S, Di Fenza R, Araujo Morais CC, Fakhr BS, Mueller AL, Yu B, Carroll RW, Ichinose F, Zapol WM, Berra L. A comparison between high dose nitric oxide delivered from pressurized cylinders and nitric oxide produced by an electric generator from air. A safety pilot study. Respir Care. 2021 Aug 19; respcare.0938. doi: 10.4187/respcare.09308. PMID: 34413210
  • Safaee Fakhr B, Di Fenza R, Gianni S, Wiegand SB, Miyazaki Y, Araujo Morais CC, Gibson LE, Chang MG, Mueller AL, Rodriguez-Lopez JM, Ackman JB, Arora P, Scott LK, Bloch DB, Zapol WM, Carroll RW, Ichinose F, Berra L, Nitric Oxide Study Investigators. Inhaled high dose nitric oxide is a safe and effective respiratory treatment in spontaneous breathing hospitalized patients with COVID-19 pneumonia. Nitric Oxide. 2021 Nov 1. doi: https://doi.org/10.1016/j.niox.2021.08.003. PMID: 34400339.
  • McKay TB, Rhee J, Colon K, Adelsberger K, Turco I, Mueller A, Qu J, Akeju O. Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery. J Cardiothorac Vasc Anesth. 2021 May 12:S1053-0770(21)00372-4. doi: 10.1053/j.jvca.2021.05.002. Epub ahead of print. PMID: 34112563.
  • Bottiroli M, Calini A, Pinciroli R, Mueller A, Siragusa A, Anelli C, Urman RD, Nozari A, Berra L, Mondino M, Fumagali R. The repurposed use of anesthesia machines to ventilate critically ill patients with coronavirus disease 2019 (COVID-19). BMC Anesthesiology. 2021 May 20. 21:155. https://doi.org/10.1186/s12871-021-01376-9
  • Katz D, Bateman BT, Kjaer K, Turner DP, Spence NZ, Habib AS, George RB, Toledano RD, Grant G, Madden HE, Butwick AJ, Lynde G, Minehart RD, Beilin Y, Houle TT, Sharpe EE, Kodali B, Bharadwaj S, Farber MK, Palanisamy A, Prabhu M, Gonzales NY, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology (SOAP) COVID-19 Registry: An analysis of outcomes among pregnant women delivering during the initial SARS-CoV-2 outbreak in the United States. Anesth Analg. 2021 Apr 8. doi: 10.1213/ANE.0000000000005592. Epub ahead of print. PMID: 33830956.
  • Ranjeva S, Pinciroli P, Hodell E, Mueller A, Hardin CC, Thompson BT, Berra L. Identifying clinical and biochemical phenotypes in acute respiratory distress syndrome secondary to coronavirus disease-2019. EClininicalMedicine. 2021 Apr; https://doi.org/10.1016/j.eclinm.2021.100829
  • Sousa GS, Fitzsimons MG, Mueller A, Quintão VC, Simões CM. Drug abuse amongst anesthetists in Brazil: a national survey. Braz J Anesthesiol. 2021 Jul-Aug;71(4):326-332. doi: 10.1016/j.bjane.2021.03.006. Epub 2021 Apr 15. PMID: 33845097; PMCID: PMC9373323.
  • Gibson LE, Fenza RD, Lang M, Capriles MI, Li MD, Kalpathy-Cramer J, Little BP, Arora P, Mueller AL, Ichinose F, Bittner EA, Berra L, G Chang M. Right Ventricular Strain is Common in Intubated Patients and Does Not Reflect Severity of Respiratory Illness. J Intensive Care Med. 2021 Mar 30;:8850666211006335. doi: 10.1177/08850666211006335. [Epub ahead of print] PubMed PMID: 33783269.
  • Xuan C, Yan W, Wang D, Mueller A, Ma H, Wang J. Effect of Preemptive Acetaminophen on Opioid Consumption: A Meta-Analysis. Pain Physician. 2021 Mar;24(2):E153-E160. PubMed PMID: 33740343.
  • Vanneman MW, Dalia AA, Crowley JC, Luchette KR, Chitilian HV, Shelton KT. A Focused Transesophageal Echocardiography Protocol for Intraoperative Management During Orthotopic Liver Transplantation. J Cardiothoracic Vasc Anesth. 2020 Jul;34(7):1824-1832.
  • Diaz-Gil D, Haerter F, Falcinelli S, Ganapati S, Hettiarachchi GK, Simons JC, Zhang B, Grabitz SD, Duarte IM, Cotton JF, Eikermann-Haerter K, Deng H, Chamberlin NL, Isaacs L, Briken V, Eikermann M. A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2. Anesthesiology. 2016 Aug;125(2):333-45.
  • Parker MJ, Lovich MA, Tsao AC, Deng H, Houle TT, Peterfreund RA. Novel Pump Control Technology Accelerates Drug Delivery Onset in a Model of Pediatric Drug Infusion. Anesth Analg. 2017 Apr;124(4):1129-1134.
  • Burns SM, Turner DP, Sexton KE, Deng H, Houle TT. Using Search Engines to Investigate Shared Migraine Experiences. Headache. 2017 Sep;57(8):1217-1227.
  • Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL. A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children. Anesthesiology. 2017 Aug;127(2):293-306.
  • Kong XY, Deng H, Alston T, Kong YG, Wang JP. Association of opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with nicotine dependence. Oncotarget. 2017 Sep 15;8(48):84329-84337.
  • Kong XY, Deng H, Gong S, Alston T, Kong YG, Wang JP. Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies. BMC Med Genet. 2017 Oct 26;18(1):120. doi: 10.1186/s12881-017-0478-4.
  • Royster RL, Deng H, Whalen SP. Postoperative Atrial Fibrillation. Anesth Analg. 2017 Jul;125(1):10-12.

Funded Grant Applications

  • NIH / 1RM1NS128741 (Brian Wainger, MD PhD): From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects.
  • NIH / R21AG073750 (Oluwaseun Johnson-Akeju, MD): Investigation of a Novel Biomarker of Postoperative Delirium.
  • FAER IARS / 2022 Mentored Research Award (Katarina Ruscic, MD): The Effects of Anesthetics on Lymphatic Vessel Contractility.
  • NIH / R01AG053582 (Oluwaseun Johnson-Akeju, MD): Pathophysiology of Postoperative Delirium and the use of Biomimetic Sleep as a Treatment Strategy in the CSICU.